Agriculture constitutes a very important sector in the Slovak economy that generates in addition to the basic food production also services, provides jobs, has a significant impact on regional development and provides nutrition of the population. One of decisive factors influencing the economic stability of agriculture is production efficiency which is strongly linked to support policy, through which partially is ensured the financial availability of enterprises. The use of subsidies by the EU is very important tool for ensuring economic sustainability of agriculture in the Slovak Republic conditions. The aim of this paper is economic evaluation of primary agricultural production in manufacturing and economic conditions in the Slovak Republic and their alternative comparison with selected EU Member States. The paper also refers to differences in level of subsidies in selected countries in the EU and their impact on possibilities of investing funds into the production development. Our calculations showed that without the intervention of the Common Agricultural Policy of the EU (especially subsidy policy) would be Slovak agriculture economically unprofitable, what could lead to its failure.