It is essential for the state to have a strategic partner at the regional level. This is justified by the fact that Lithuania decided to turn into an active regional country while reducing the possible threat from Russia. The potential alliance of Lithuania and Poland should be the most rational direction of the strategic partnership. In attempting to justify this assumption the geopolitical interests of Lithuania and Poland, its coherence and compatibility, are examined. Conditions strengthening the development of the strategic partnership are reviewed. The most plausible scenarios of further co-operation between Lithuania and Poland are also presented.