This article analyzes the transatlantic relations and cooperation challenges between the U.S.A. and the EU. The first part of the article covers the conditions for the functioning of transatlantic relations, the main actors and their roles in contemporary world order, and also the international system and the placement of the EU and U.S.A. within it. Other factors which have an essential influence on a successful relationship between these 2 actors are discussed as well. The second part of the article is dedicated for the assessment of factors and presumptions about the U.S.-EU contest and cooperation. The article concludes with remarks highlighting the economical presumptions to developing transatlantic relations and turns the audiences attention to necessities in which to strengthen this political model, by making a review of the political and ideological relationship, evaluating requirements of the world order, image and also aspects for future visions. Changes in the role of international organizations, more clearly expressed EU member states sovereignty and U.S. unilateral politics, remain potential sources of challenges for the US-EU relations.