As a result of the conducted study, there has been solved an important scientific problem of development of theoretical and methodological foundations of building international competitiveness in the conditions of globalization of innovation activity and creation of organizational and economic tools for support of national innovation system safety in global scientific and technological space. It has been established that innovation activity in Poland is characterized by structural deformation, institutional incompleteness, inconsistency and imbalance of technological, economic, social and value aspects, as a result of which innovation processes in the country have not gained sufficient scale and are not a significant factor of GDP growth. Problems of development of national innovation systems in Poland are caused, first of all, by an unsatisfactory state of financing of the scientific sphere, as a result of which the country has lost the system capable to effectively concentrate resources on priority strategic directions of innovation development. Based on a comparative economic and mathematical analysis of the impact of variables that determine the degree of inclusion of the country in global value chains, as well as diagnostics of the competitive environment of some countries, it has been stated that, except for IT, today Poland has no competitive advantages and preconditions for inclusion in global value chains. Considering the importance of the human development index, the Chinese model of innovation development is most acceptable for the country. Considering that in addition to the financial component, one of the main reasons for slowing down innovation activity in Poland is the lack of effective links between government, business and science, there has been justified the need to develop a government innovation policy based on a combination of direct and indirect methods of innovation support. There has been stressed the importance of building a common information and scientific space with Europe, which is possible in the conditions of creation of an open national innovation system.