This study aims to look at the effect of the investment amount of labor and the minimum wage to economic growth. This study use PLS, and use time series data from 2010 to 2016. The variables in this research are domestic investment variable physical, minimum wage, and the amount of labor work in Indonesia. The results showed that the physical variables domestic investment, domestic investment in non-physical, minimum wage, and the number of workers who work GRDP of East Java but for variable non-physical investments in the country negatively affect the Gross Regional Domestic Product of East Java.