The article solves the current scientific problem of substantiation of theoretical and methodological bases of forecasting the regional aspect of ensuring economic security of the national economy and the development of conceptual guidelines and practical recommendations for improving management processes. The impact of threats on the economic security of the regions was determined. The use of cluster analysis tools allowed to determine the impact of socio-economic development factors on the economic security of the regions. It was established that the economic security of the “Higher”regional cluster is affected by such threats as the loss of sales markets, reduction of protection and rational use of natural resources, the level of control over corruption, political stability and the absence of violence/terrorism. The economic security of the “Average”regional cluster is affected by declining political stability and the absence of violence/terrorism, protection and rational use of natural resources, loss of sales markets, reduction of human development level, efficiency of state power, supremacy of the law. The economic security of the “Lower”regional cluster is affected by the loss of sales markets, declining human development level, control over corruption, efficiency of state authority, political stability and the absence of violence/terrorism, protection and rational use of natural resources. It is recommended to develop the Strategy of economic development of regions on the basis of the world experience for the purpose of ensuring economic security of national economy of the country.