This scientific paper considers the essence of investment, financial and operational activity of the enterprise in the context of provision of a high level of its economic security, and describes the importance of investment support for the economic activity of the enterprise and the place of investments for the factor of economic security. The method of estimation of investment, financial and operational risks based on matrix and expert approaches was offered. The modelling of the systemic risk impact on the economic security of the enterprise was performed and recommendations on the neutralization of the influence of risks were developed.