In order to form an effective analytical support for the management of the economic and environment safety of organizations, the initial positions of environmental and economic analysis were substantiated. This allowed expanding the understanding of economic analysis in ensuring the effective interaction of the organization with the environment. As a result of the study of the methods of environmental and economic analysis of the priority objects of management of economic and environment safety, the absence of a system of indicators and a mechanism for their use has been established, which significantly reduces the quality level of the management information space. In order to solve this problem, the work developed the author’s methods of environmental and economic analysis:1) models of environmental and economic analysis of the production process in terms of waste management (proposed calculation procedure, interaction mechanism, information support, procedure for factor models construction of waste cost ratios, waste capacity ratios, waste replacement ratios, waste replacement efficiency ratios); 2) procedure for analyzing the cost of processing, recycling and disposal of waste. The use of these techniques allowed us to identify the reserves for increasing the level of environmental and economic security of organizations.