The article determines the factors of effectiveness of the formation of the organizational culture of the enterprise and its role in ensuring personnel security. It was proven that an enterprise can improve the quality of personnel security by developing an organizational culture in order to obtain positive dynamics of changes in economic efficiency indicators. An econometric model was proposed for determining the level of dependence of economic parameters of an enterprise on the directions of development and transformation of organizational culture. A tool for assessing the state of the organizational culture of the enterprise and assessing its impact on personnel security was proposed.